Phyto Chemicals

 

  • Lysergol-imageLysergol, is an alkaloid of the ergoline family that occurs in various species of vines of the Convolvulaceae and some species of fungi. As the minor alkaloid in the hallucinogenic seeds of Rivea corymbosa (ololiuhqui), Argyreia nervosa (Hawaiian baby woodrose) and Ipomoea violacea (tlitliltzin).

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    • Yuan, Haosen; Guo, Zhixian; Luo, Tuoping (2017). “Synthesis of (+)-Lysergol and Its Analogues To Assess Serotonin Receptor Activity”. Organic Letters. ISSN1523-7060. doi:1021/acs.orglett.6b03779.
    • Itoh T, Shigemoto T, Shimizu N, Tamura T, Matsumoto T. Triterpene alcobols in the seeds of two cucumis species of cucurbitaceae. Phytochemistry. 1982;21:2414–5.
    • Rizvi SH, Shoeb A, Kapil RS, Popli SP. Two new diuretic triterpenoids from Antidesma menasu. Phytochemistry. 1980;19:2409–10.
    • Jorjani MH. Qom: Institute of Natural Medicine Resurgence; 2012. Kharazmid Reservoir (Zakhire Kharazmshahi) p. 409.
    • Nazem Jahan MA. Vol. 1. Tehran: Research Institute for Islamic and Complementary Medicine; 2008. Great Panacea (Exir Azam) p. 111.

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  • nicergolineNicergoline is an ergoloid mesylate derivative used to enhance mental clarity, perception and concentration. Nicergoline, currently being used in the battle to treat senile dementia, has been found to improve mental agility through enhancing perception and vigilance. In this way it differs from the effects of Hydergine® (to which it is chemically similar) which improves oxygen stability and increases mental ability.

    Nicergoline has alpha-adrenolytic action which activates the brain’s metabolism and improves arterial flow, lowers vascular resistance and improves the use of glucose and oxygen. Furthermore, it is known that Nicergoline inhibits platelet aggregation, and, animal experiments have shown, it increases nerve growth in the aged brain.

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  • Reserpine-imageReserpine is a naturally occurring drug that has been used for centuries in ancient India. It is extracted from the root of Rauwolfia serpentina or Rauwolfia vomitoria, plants found in India and Africa. In traditional herbal medicine, the root was brewed as a tea and used in humans to treat hypertension, insanity, snakebite, and cholera. The purified alkaloid, reserpine, was isolated in 1952 and is considered the first modern drug for the treatment of hypertension. Reserpine irreversibly binds to the storage vesicles of neurotransmitters, particularly norepinephrine, serotonin and dopamine. Eventually, catecholamine depletion occurs because of the body’s inability to store these neurotransmitters. It is an unusual drug; it takes many hours or days to reach full effect and continues to have some subtle sedating effects for many days after the last dose.

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  • trioxsalenTrioxsalen (trye-OX-sa-len) belongs to the group of medicines called psoralens. It is used along with ultraviolet light (found in sunlight and some special lamps) in a treatment called psoralen plus ultraviolet light A (PUVA) to treat vitiligo, a disease in which skin color is lost. Trioxsalen may also be used for other conditions as determined by your doctor.

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    • Trioxsalen – Compound Summary”.
    • Van Coevorden, AM; Kamphof, WG; Van Sonderen, E; Bruynzeel, DP; Coenraads, PJ (2004). “Comparison of oral psoralen-UV-A with a portable tanning unit at home vs hospital-administered bath psoralen-UV-A in patients with chronic hand eczema: an open-label randomized controlled trial of efficacy.”. Archives of dermatology. 140 (12): 1463–6. PMID15611423. doi:1001/archderm.140.12.1463.
    • Thazhathveetil, AK; Liu, ST; Indig, FE; Seidman, MM (2007). “Psoralen conjugates for visualization of genomic interstrand cross-links localized by laser photoactivation”. Bioconjugate chemistry. 18 (2): 431–7. PMID17373769. doi:1021/bc060309t.
    • Higuchi, M; Yamayoshi, A; Kobori, A; Yamaoka, T; Murakami, A (2005). “Synthesis and properties of photo-reactive antisense oligonucleotides containing 2′-O-psoralen-conjugated adenosine”. Nucleic acids symposium series (2004). 49 (49): 331–2. PMID17150768. doi:1093/nass/49.1.331.

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